[ Expériences ]

1er test synthacaine TR

Dernière modification par kav (05 novembre 2013 à  08:58)

Sur 5 produits appelés “NRG-3”³, une analyse a été réalisée par le laboratoire de toxicologie de Lariboisière:

La composition varie en quantité mais aussi en qualité avec une variation importante des substances psychoactives retrouvées.

La nature des cathinones retrouvée est différente en structure et également en terme de propriétés pharmacologiques.

Les usagers de drogues, et les médecins doivent savoir que le nom du packaging (NRG-3) ne présume pas du contenu et donc des effets de la drogue.

http://addictovigilance.aphp.fr/2013/10 … nes-nrg-3/

A large number of cathinone derivatives have shown a wide range of bioactive properties, attracting great interest from communities associated with pharmaceutical research. Some of these derivatives have gained popularity as so-called recreational ‘legal highs’ due to their availability on the Internet and high street shops. A previous study described the qualitative analysis of 24 ‘legal high’ Energy-1 (NRG-1) and NRG-2 products obtained from 18 websites following the ban on mephedrone and derivatives in April 2010. The majority of these products contained a mixture of cathinones just carrying a new label. Here, three additional cathinone products have been detected; two from an NRG-1 sample and one from an NRG-3 sample. This report describes their identification. NRG-1 sample 1 consisted of a mixture of 4 cathinones namely 4-fluoromethcathinone (1), 1-(3,4-methylenedioxyphenyl)-2-(methylamino)pentan-1-one (pentylone, 2), 3,4-methylenedioxy-α-pyrrolidinobutyrophenone (MDPBP, 3) and 3,4-methylenedioxypyrovalerone (MDPV, 4). The sample labelled as NRG-3 (mislabelled with the chemical structure of mephedrone) consisted of a mixture of 4-methyl-α-pyrrolidinopropiophenone (MPPP, 5) and (2), whereas the remaining NRG-1 sample 2 (also mislabelled with the chemical structure of mephedrone) consisted of a mixture of (2) and (3). Qualitative analyses were carried out by GC-(EI/CI)-MS, NMR spectroscopy and confirmation by preparation of standards. The preparation of brominated precursors carrying the 3,4-methylenedioxyphenyl nucleus revealed extensive α,α-dibromination: the mass spectral and NMR data of these intermediates are also presented and discussed.

http://onlinelibrary.wiley.com/doi/10.1 … 4/abstract

Déjà  qu'on ne connaît pas les effets à  moyen/ long terme d'UNE SEULE de ces substances, alors les combiner dans des proportions inconnues me semble pour le moins...aléatoire (et risqué) !!!

Dernière modification par Jhi-dou (05 novembre 2013 à  12:38)